Scientific programm: Abstract

2nd scientific session: (Core) PPV

9. Non-steroidal Anti-inflammatory Drugs
    in Vitrectomy Surgery

Kourous A. Rezaei (Harvey)

Purpose: To analyze the characteristics and outcome of patients who developed macular edema after vitrectomy surgery and were successfully treated with a combination of non-steroidal anti-inflammatory drugs and steroid eye drops.
Methods: Retrospective case series of patients who were successfully treated with a combination of nepafenac ophthalmic suspension and steroid eye drops for macular edema after vitrectomy surgery for a variety of vitreo-retinal disorders. 10 patients were included in the study from December 2006 till April of 2009. The mean age was 60.3 years (range 47-87 years). 6 of the patients were male. 4 Patients underwent vitrectomy surgery for retinal detachment (2 of them with epiretinal membrane peel), 1 patient for neovascular glaucoma, 2 patients for epiretinal membrane, 1 patient for macular hole, 1 patient for vitreous hemorrhage, and 1 patient for proliferative diabetic retinopathy.
Results: The mean duration of treatment was 4.1 moths (range 1-18 months). The mean OCT thickness prior to the topical treatment with nepafenac ophthalmic suspension and corticosteroid eye drops was 407 microns (range 294-521 microns). The mean OCT thickness after the topical treatment was 282.1 microns (range 182-357 microns). The mean visual acuity prior to the initiation of topical treatment was 20/150 (range 20/60 – 20/400). The mean visual acuity after the topical treatment was 20/50 (range 20/40 – 20/150). None of the patients experienced any significant adverse effect from the topical treatment.
Conclusions: OCT exam following successful vitrectomy surgery in patients with visual acuity less than 20/20 may indicate the presence of macular edema. This macular edema can be successfully treated with a combination of non-steroidal anti-inflammatory drugs i.e. nepafenac ophthalmic suspension and corticosteroid eye drops leading to a reduction of macular edema and improved visual acuity.

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